The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

The immune system is a tightly regulated network which allows the development of defense
mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells …

Older organs represent an untapped potential to close the gap between demand and supply
in organ transplantation but are associated with age-specific responses to injury and …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …