Heart disease is a leading cause of death with unmet clinical needs for targeted treatment
options. Tumor necrosis factor alpha (TNF-α) represents a master pro-inflammatory cytokine …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

In response to myocardial infarction (MI), the wound healing response of the left ventricle
(LV) comprises overlapping inflammatory, proliferative, and maturation phases, and the …

Heart failure is a global health problem, appearing most commonly in patients with previous
myocardial infarction (MI). Cardiac remodelling, particularly fibrosis, seen in both the …

Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM)
and normal cells, in particular tumour-associated macrophages (TAM). To understand the …

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-
inflammatory to reparative responses, and the cardiac fibroblast is a central player during …

Myocardial infarction leads to scar formation and subsequent reduced cardiac performance.
The ultimate therapy after myocardial infarction would pursue stem cell-based regeneration …

In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs)
to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for …

The inflammatory milieu of acute myocardial infarction (MI) is theoretically conducive to
enhanced cytokine synthesis within the brain. We tested the hypothesis that synthesis of …