Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis
investigates TNF in triggering the expression and activation of matrix metalloproteinases …

Abstract [eng] In this study, there were established the first myogenic stem cell lines derived
from adult rabbit skeletal muscle. The study revealed the ability of such cells to be …

Es konnte erstmals gezeigt werden, dass Tumor Nekrose Faktor-α (TNF-α)(TNF-α) in
pathophysiologisch relevanten Konzentrationen neben seiner bekannten negativ inotropen …

ÖZET Kök/öncül hücreler ile nonhematopoietik doku onarımında gerçekleşen moleküler
olaylar halen yeterince açıklığa kavuşturulamamış gizemli ve karmaşık mekanizmaları …

Cardiac fibroblasts (CFs) are the predominant cell type in the cardiac tissue and play a vital
role in wound healing, hypertrophy and fibrosis. During heart failure there is accumulation of …

This work is devoted to elucidation of the role of disorders of prooxide-antioxide system,
changes in humoral immunity, phagocytosis and endogenous intoxication in the dynamics of …

Following myocardial infarction (MI), cardiac fibroblasts (CF) proliferate, undergo
myofibroblast transformation and generate excess extracellular matrix (ECM). Increased …

Fibrogenesis is essential for infarct healing and affects ventricular remodeling, one of the
most important prognostic factors after myocardial infarction. Fibrogenesis is initiated by a …

Objective: Tumor necrosis factor A (TNFA) is implicated in myocardial remodeling, a process
in which activated cardiac fibroblasts (myofibroblasts) secrete matrix-degrading …

Cardiomyopathies are often initiated by diastolic dysfunction, and treatment of diastolic
dysfunction remains empirical with an emphasis on prevention. This dissertation focuses on …