In present study a series of triazolopyrimidine-quinoline and cyanopyridine-quinoline
hybrids were designed, synthesized and evaluated as acetylcholinesterase inhibitors …

In this study, we investigated the effects of the memory-enhancing drugs piracetam,
vincamine, and vinpocetine or the cholinesterase inhibitor donepezil on the development of …

With the increasing demand of new drugs for the treatment of Alzheimer's disease (AD),
screening acetylcholinesterase (AChE) inhibitors from traditional Chinese medicines (TCMs) …

The discovery of acetylcholine and acetylcholinesterase provided the first insight into the
intricacies of chemical signal transduction and neuronal communication. Further elucidation …

Alzheimer's disease (AD) is an age-related neurodegenerative disease linked with
increased production and/or deposition of amyloid-beta (Aβ) in the brain. The aim of the …

A series of tacrine–rhein hybrid compounds have been designed and synthesized as novel
multifunctional potent ChE inhibitors. Most of the compounds inhibited ChEs in the …

A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo [1, 2-b]
phthalazine structure were designed and synthesized as potent and selective inhibitors of …

Medicinal plants have been documented as an important source for discovering new
pharmaceutical molecules that have been used to treat serious diseases. Strikingly …

Amaryllidaceae plants are the commercial source of galanthamine, an alkaloid approved for
the clinical treatment of Alzheimer's disease. The chemistry and bioactivity of Chilean …

A series of novel chalcone-rivastigmine hybrids were designed, synthesized, and tested in
vitro for their ability to inhibit human acetylcholinesterase and butyrylcholinesterase. Most of …