Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Targeted therapy is considerably changing the treatment and prognosis of cancer.
Progressive understanding of the molecular mechanisms that regulate the establishment …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

The low-voltage activated T-type calcium channels regulate cellular excitability and
oscillatory behavior of resting membrane potential which trigger many physiological events …

Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …

The calcium channel antagonists are a mature group of drugs directed at cardiovascular
diseases including hypertension, angina, peripheral vascular disorders and some …

Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse
set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx …

Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early
development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a …

Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell
proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and …

Background Patients with glioblastoma multiforme, the most aggressive form of glioma, have
a median survival of approximately 12 months. Calcium (Ca 2+) signaling plays an important …