Calcium ions (Ca2+) act as second messengers in intracellular signaling. Ca2+ pumps,
channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular …

Ca2+ signalling is involved in virtually all cellular processes: among the others, it controls
cell survival, proliferation and death regulating a plethora of intracellular enzymes located in …

Microparticles (MPs) are released from most eukaryotic cells after the vesiculation of the
plasma membrane and serve as vectors of long and short-range signaling. MPs derived …

Pimozide is currently being used in clinic as a neuroleptic and exerts versatile biological
actions. Pimozide is a cationic amphiphilic drug (CAD); CADs block the synthesis of neutral …

Background Understanding the cause of therapeutic resistance and identifying new
biomarkers in breast cancer to predict therapeutic responses will help optimise patient care …

Drug repurposing is the idea of using an already approved drug for another disease or
disorder away from its initial use. This new approach ensures the reduction in high cost …

Transient receptor potential (TRP) channels sense and transduce environmental stimuli into
Ca 2+ transients that in turn induce responses essential for cell function and adaptation …

Environmental estrogen mimics, including metalloestrogens that can activate estrogen
receptor-alpha (ERα), may contribute to breast cancer risk. However, the underlying …

Malignant mesothelioma is a poor prognosis cancer in urgent need of alternative therapies.
Oleuropein, the major phenolic of olive tree (Olea europaea L.), is believed to have …

T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we
summarize the recent advances and new insights into TTCC biology, tumor progression …