BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

Infertility affects 10% of reproductive-age women and is extremely heterogeneous in
etiology. The genetic contribution to female infertility is incompletely understood, and …

All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …

Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …

Mammalian oocytes are surrounded by an extracellular coat called the zona pellucida (ZP),
which, from an evolutionary point of view, is the most ancient of the coats that envelope …

Empty follicle syndrome (EFS) is the complete failure to retrieve oocytes after ovarian
stimulation. Although LHCGR and ZP3 were identified as causative genes, it is still unclear …

Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP),
whose ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a …

Purpose Mutations in the zona pellucida glycoprotein genes have been reported to be
associated with empty follicle syndrome (EFS) and abnormal zona pellucida (ZP). In this …

Objective To identify the major causative gene (s) of genuine empty follicle syndrome
(GEFS) characterized by oocyte degeneration. Design Genetic and functional studies …