Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs

N Eskandarzade, A Ghorbani, S Samarfard… - Computers in biology …, 2022 - Elsevier
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …

Analysis of age-dependent gene-expression in human tissues for studying diabetes comorbidities

PH Guzzi, F Cortese, GC Mannino, E Pedace… - Scientific Reports, 2023 - nature.com
The study of the relationship between type 2 diabetes mellitus (T2DM) disease and other
pathologies (comorbidities), together with patient age variation, poses a challenge for …

Differential network analysis between sex of the genes related to comorbidities of type 2 mellitus diabetes

PH Guzzi, F Cortese, GC Mannino, E Pedace… - Applied Network …, 2023 - Springer
Background Some phenotypical changes may be related to changes in the associations
among genes. The set of such associations is referred to as gene interaction (or association) …

GTExVisualizer: a web platform for supporting ageing studies

PH Guzzi, U Lomoio, P Veltri - Bioinformatics, 2023 - academic.oup.com
Motivation Studying ageing effects on molecules is an important new topic for life science.
To perform such studies, the need for data, models, algorithms, and tools arises to elucidate …

LncRNA SNHG1 promotes renal cell carcinoma progression through regulation of HMGA2 via sponging miR‐103a

Z Ye, D Gui, X Wang, J Wang… - Journal of Clinical …, 2022 - Wiley Online Library
Abstract Background Long noncoding RNAs (LncRNAs) plays a vital role in tumorigenesis
and development. The molecular mechanism of SNHG1 in renal cell carcinoma (RCC) has …

SARS-CoV-2 protein structure and sequence mutations: Evolutionary analysis and effects on virus variants

U Lomoio, B Puccio, G Tradigo, PH Guzzi, P Veltri - Plos One, 2023 - journals.plos.org
The structure and sequence of proteins strongly influence their biological functions. New
models and algorithms can help researchers in understanding how the evolution of …

The association between obesity with treatment duration, ICU length of stay and the risk of death in critically ill patients with COVID‐19

M Gholamalizadeh, M Attari, M Mousavi… - Endocrinology …, 2023 - Wiley Online Library
Background Despite the confirmed association between higher BMI with increased risk of
the acute respiratory distress syndrome (ARDS), the association between obesity with …

Identifying multimorbidity profiles associated with COVID-19 severity in chronic patients using network analysis in the PRECOVID Study

J Carmona-Pírez, A Gimeno-Miguel, K Bliek-Bueno… - Scientific Reports, 2022 - nature.com
A major risk factor of COVID-19 severity is the patient's health status at the time of the
infection. Numerous studies focused on specific chronic diseases and identified conditions …

Using smart devices for monitoring elderly patients in rural areas of calabria after covid-19 vaccination: Experiences within the si4care project

A Gallo, S Fregola, M Menon, F Talarico, S Fragkiadaki… - COVID, 2023 - mdpi.com
The SI4CARE project is a transnational project which aims to develop both strategy and
action plans to improve health and social care in the Adriatic–Ionian region. Starting from a …

Bioinformatics and system Biology approach to reveal the interaction network and the therapeutic implications for non-small cell lung cancer patients With COVID-19

Z Zhuang, X Zhong, Q Chen, H Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the leading
cause of coronavirus disease-2019 (COVID-19), is an emerging global health crisis. Lung …