Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …

There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell
swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This …

Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context
of inflammation and atherosclerosis development. While present in plasma during …

Oxidative modification of LDL is known to elicit an array of pro-atherogenic responses, but it
is generally underappreciated that oxidized LDL (OxLDL) exists in multiple forms …

The Lands Pathway is a fundamental biochemical process named for its discovery by
William EM Lands and revealed in a series of seminal papers published in the Journal of …

Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is
associated with a variety of diseases, but the exact identity of LPC receptors remains …

Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …