Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

Liver cancer is the third leading cause of cancer-related death worldwide. Advances in
sequencing technologies have enabled the examination of liver cancer genomes at high …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

Numerous genetic alterations are accumulated during the process of hepatocarcinogenesis.
These genetic alterations can be divided into two groups. The first set of genetic alterations …

Hepatocellular carcinoma (HCC) is one of the human cancers clearly linked to viral
infections. Although the major viral and environmental risk factors for HCC development …

Patients with neurofibromatosis 1 (NF1) are predisposed to develop multiple neurofibromas
(NFs) and are at risk for transformation of NFs to malignant peripheral nerve sheath tumors …

A study was conducted to examine the significance of genetic instability and aberrant DNA
methylation during hepatocarcinogenesis. Genomic DNA was extracted from 196 …

Abstract The 14-3-3 σ gene has been implicated in G2/M cell cycle arrest by p53. Frequent
inactivation of the 14-3-3 σ gene by hypermethylation of CpG islands has recently been …

Hepatocellular carcinoma is the third most frequent cause of cancer-related death
worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses …