Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

A simple purification method has been developed for isolation of bovine cGMP
phosphodiesterase from pho toreceptor rod outer segments. The enzyme is periph erally …

Biochimica et Biophysica .4cta, 463 (1977) 91-125 Department of Biological Sciences, Purdue
University, West LaJayette, Ind. 479 Page 1 Biochimica et Biophysica .4cta, 463 (1977) 91-125 …

Few high affinity inhibitors of the photoreceptor phosphodiesterases have been identified.
We show here that dipyridamole and M&B 22,948 (Zaprinast), potent inhibitors of the cGMP …

The elucidation of the cellular and molecular bases underlying the inte grated function of the
central nervous system, both in disease and in health, must ultimately come from the …

It is difficult to present to chemists a comprehensive view of a biological process such as
vision: they are usually familiar only with the “molecular” language, while the overall process …

ABSTRACT A guanosine 3*: 5*-monophosphate-specific phosphodiesterase (cyclic GMP-
PDE) from guinea pig lung was purified 250-fold over the activity present in crude extracts …

Retinal rod outer segment phosphodiesterase (PDE) consists of two similar catalytic
subunits (alpha and beta) and two identical inhibitory subunits (gamma 2). A trypsin …

Considerable evidence has accumulated suggesting that cyclic nucleotides play an
important role in the metabolism and function of the retina. Furthermore, abnormalities in the …

The localization of guanylate cyclase in bovine adrenal medulla was explored by
preparation of subcellular organelles. Forty per cent of the activity was recovered in the …