Recent advances in codelivery of curcumin and siRNA as anticancer therapeutics

M Sanati, AR Afshari, P Kesharwani… - European Polymer …, 2023 - Elsevier
Addressing the need for effective cancer chemotherapy with low adverse effects has been
partially possible through innovative therapeutic approaches combining chemotherapeutics …

Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances

A Hussain, A Kumar, V Uttam, U Sharma, K Sak… - Environmental …, 2023 - Elsevier
Curcumin, derived from turmeric, has a strong anticancer potential known for millennia. The
development of this phytochemical as a medicine has been hampered by several significant …

Natural compounds targeting nuclear receptors for effective cancer therapy

M Hegde, S Girisa, N Naliyadhara, A Kumar… - Cancer and Metastasis …, 2023 - Springer
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Y Zhou, Y Kong, M Jiang, L Kuang, J Wan… - Cancer biology & …, 2022 - Taylor & Francis
Curcumin, the primary bioactive component isolated from turmeric, has been found to
possess a variety of biological functions, including anti-leukemia activity. However, the effect …

[HTML][HTML] Development of PEGylated PLGA nanoparticles co-loaded with bioactive compounds: potential anticancer effect on breast cancer cell lines

S Mohammadinejad… - Asian Pacific journal …, 2022 - ncbi.nlm.nih.gov
Objective: The incidence of breast cancer continues to rise despite decades of laboratory,
epidemiological and clinical research. Breast cancer is still the leading cause of cancer …

Topical advances in PIM kinases and their inhibitors: Medicinal chemistry perspectives

V Walhekar, C Bagul, D Kumar, A Muthal… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Cytosolic PIM kinases are the members of serine/threonine family play a crucial role in the
cancer progression and development. Overexpression of PIM kinases is observed in various …

A co-carrier for plasmid DNA and curcumin delivery to treat pancreatic cancer via dendritic poly (l-lysine) modified amylose

J Pang, B Zhuang, LM Zhang - International Journal of Biological …, 2023 - Elsevier
Pancreatic cancer is one of the most lethal malignancies in the world and remains one of the
leading causes of cancer related death. For its treatment, a lot of investigations have dealt …

[HTML][HTML] Emerging trends in curcumin embedded electrospun nanofibers for impaired diabetic wound healing

GP Tamilarasi, M Krishnan, G Sabarees, S Gouthaman… - Applied Nano, 2022 - mdpi.com
Chronic wounds impose a significant burden on individuals and healthcare systems all over
the world. Through clinical and preclinical investigations, inflammation and oxidative …

Curcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor‐associated macrophages and metastasis associated in colon …

S Ge, X Sun, L Sang, M Zhang, X Yan… - Chemical Biology & …, 2023 - Wiley Online Library
The present study was to investigate the underlying mechanism of the antitumor effect of
curcumin in colorectal cancer cells, focusing on the M2 polarization of tumor‐associated …

[HTML][HTML] Multiple myeloma inhibitory activity of plant natural products

K Jöhrer, SS Ҫiҫek - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma is the second most common hematological cancer and
is still incurable. Although enhanced understanding of the disease background and the …