B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among
hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of …

Abstract Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status
has been well documented to have physiologic benefits in human health. However, the …

Interleukin (IL)-33 is a chromatin-related nuclear interleukin that is a component of IL-1
family. IL-33 production augments the course of inflammation after cell damage or death. It is …

Background: Multiple myeloma (MM) is the second most common hematological
malignancy, which is still incurable and relapses inevitably, highlighting further …

Differentiation therapy is attracting increasing interest in cancer as it can be more specific
than conventional chemotherapy approaches, and it has offered new treatment options for …

Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower
CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy …

A previous study has demonstrated a significant decrease in the TCRζ gene expression
level in chronic myeloid leukemia (CML); thus, we further investigated the expression of …

Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of
clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16 …

Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role
in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated …

It is now clear that chronic lymphocytic leukemia (CLL) is a proliferative disorder that
requires the help of its microenvironment to be maintained and to progress. In CLL …