The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Though clinical trials for medical applications of dimethyl sulfoxide (DMSO) reported toxicity
in the 1960s, later, the FDA classified DMSO in the safest solvent category. DMSO became …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …

Since both myocardium and vasculature in the heart are excessively damaged following
myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Smart piezoelectric materials are of great interest due to their unique properties.
Piezoelectric materials can transform mechanical energy into electricity and vice versa …