Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted …

M Liao, R Qin, W Huang, HP Zhu, F Peng… - Journal of Hematology & …, 2022 - Springer
Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

[HTML][HTML] Autophagy and renal fibrosis

S Liang, YS Wu, DY Li, JX Tang, HF Liu - Aging and disease, 2022 - ncbi.nlm.nih.gov
Renal fibrosis is a common process of almost all the chronic kidney diseases progressing to
end-stage kidney disease. As a highly conserved lysosomal protein degradation pathway …

Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy

D Liu, H Zhu, C Li - Biomarker Research, 2023 - Springer
Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …

Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives

AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

The FOXO family of transcription factors: key molecular players in gastric cancer

Y Liu, X Ao, Y Jia, X Li, Y Wang, J Wang - Journal of Molecular Medicine, 2022 - Springer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death with an oncological origin. Despite its decline in …

Hesperidin ameliorates sarcopenia through the regulation of inflammaging and the AKT/mTOR/FoxO3a signaling pathway in 22–26-month-old mice

HJ Oh, H Jin, BY Lee - Cells, 2023 - mdpi.com
Faced with a globally aging society, the maintenance of health and quality of life in older
people is very important. The age-related loss of muscle mass and strength, known as …

Rheostatic balance of circadian rhythm and autophagy in metabolism and disease

X Wang, Z Xu, Y Cai, S Zeng, B Peng, X Ren… - Frontiers in Cell and …, 2020 - frontiersin.org
Circadian rhythms are physical, behavioral and environmental cycles that respond primarily
to light and dark, with a period of time of approximately 24 h. The most essential …