Background Expanding outbreaks of circulating vaccine-derived type 2 poliovirus (cVDPV2)
across Africa after the global withdrawal of trivalent oral poliovirus vaccine (OPV) in 2016 …

After the globally coordinated cessation of any serotype of oral poliovirus vaccine (OPV),
some risks remain from undetected, existing homotypic OPV‐related transmission and/or …

Serotype 2 oral poliovirus vaccine (OPV2) can revert to regain wild-type neurovirulence and
spread to cause emergences of vaccine-derived poliovirus (VDPV2). After its global …

Background The polio environmental surveillance (ES) system has been an incredible tool
for advancing polio eradication efforts because of its ability to highlight the spatial and …

The number and geographic breadth of circulating vaccine-derived poliovirus type 2
(cVDPV2) outbreaks detected after the withdrawal of type 2 containing oral polio vaccine …

For more than 20 years, the World Health Organization Western Pacific Region (WPR) has
been polio-free. However, two current challenges are still polio-related. First, around half of …

The emergence of circulating vaccine-derived polioviruses through evolution of the oral
polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the …

Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients
and susceptible contacts or evolve to become circulating vaccine-derived strains with the …

Genetic sequencing of polioviruses detected through clinical and environmental
surveillance is used to confirm detection, identify their likely origin, track geographic patterns …

The oral poliovirus vaccines (OPVs) are one of the most effective disease eradication tools
in public health. However, the OPV strains are genetically unstable and can cause …