The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Since being first described more than 60 years ago, Na, K-ATPase has been extensively
studied, while novel concepts about its structure, physiology, and biological roles continue to …

The ongoing pandemic caused by the novel coronavirus, SARS-CoV-2, is influencing global
health. Moreover, there is a major threat of future coronaviruses affecting the entire world in …

SARS-CoV-2 infection across the world has led to immense turbulence in the treatment
modality, thus demanding a swift drug discovery process. Spike protein of SARS-CoV-2 …

Background New therapeutic options to address the ongoing coronavirus disease 2019
(COVID-19) pandemic are urgently needed. One possible strategy is the repurposing of …

Tylophorine-based compounds exert broad spectral, potent inhibition of coronaviruses. NF-
κB activation is a common pro-inflammatory response of host cells to viral infection. The …

Glycosides represent a large group of secondary metabolic products derived from plants,
demonstrating several known functions, including growth regulation, allelopathy (inhibition …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified for the first time
in Wuhan, China, causes coronavirus disease 2019 (COVID-19), which moved from …

COVID-19 pandemic poses a severe threat to public health. However, so far, there are no
effective drugs for COVID-19. Transcriptomic changes and key genes related to Th2 cells in …

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and
bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors …