Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by
immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation …

Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …

The clinical and prognostic relevance of many recently identified driver gene mutations in
adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or …

Background Acute myeloid leukemia (AML) is a heterogeneous disease with respect to
presentation and clinical outcome. The prognostic value of recently identified somatic …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …

Recent genomic studies have identified novel recurrent somatic mutations in patients with
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …

Summary TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in
various biological processes. Mutations of TET2 are frequently observed in myeloid …

Prognostic Significance of the European LeukemiaNet Standardized System for Reporting
Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia - PMC Back to …