The promise of targeting epigenetic abnormalities for cancer therapy has not been realized
for solid tumours, although increasing evidence is demonstrating its worth in haematological …

Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …

We report the first large-scale exome-wide analysis of the combined germline–somatic
landscape in ovarian cancer. Here we analyse germline and somatic alterations in 429 …

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …

To clarify the cooperative roles of recurrently identified mutations and to establish a more
precise risk classification system in acute myeloid leukemia (AML), we comprehensively …

Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and
TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice …

The studies concerning clinical implications of TET2 mutation in patients with primary acute
myeloid leukemia (AML) are scarce. We analyzed TET2 mutation in 486 adult patients with …

Cancer is a heterogeneous disease with different combinations of genetic alterations driving
its development in different individuals. We introduce CoMEt, an algorithm to identify …

RUNX1 Mutations Are Associated With Poor Outcome in Younger and Older Patients With
Cytogenetically Normal Acute Myeloid Leukemia and With Distinct Gene and MicroRNA …

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia
(AML) have identified frequent somatic mutations in genes that encode proteins important in …