[HTML][HTML] Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy

MKK Chan, ELY Chan, ZZ Ji, ASW Chan… - … of Targeted Anti …, 2023 - ncbi.nlm.nih.gov
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the
pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are …

Targeting TGF-β signaling in the multiple myeloma microenvironment: Steering CARs and T cells in the right direction

PS Rana, DC Soler, J Kort, JJ Driscoll - Frontiers in Cell and …, 2022 - frontiersin.org
Multiple myeloma (MM) remains a lethal hematologic cancer characterized by the expansion
of transformed plasma cells within the permissive bone marrow (BM) milieu. The emergence …

Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

C Quinn, MC Rico, C Merali, CA Barrero… - Science Translational …, 2023 - science.org
Hepatic fibrosis is the primary determinant of mortality in patients with metabolic dysfunction–
associated steatohepatitis (MASH). Transforming growth factor–β (TGFβ), a master …

[HTML][HTML] Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets

BM Hussen, HJ Hidayat, SR Abdullah, S Mohamadtahr… - Cytokine, 2023 - Elsevier
The cytokine known as transforming growth factor (TGF) is essential for cell development,
differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor …

Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication

A Stavropoulos, G Divolis, M Manioudaki, A Gavriil… - Science …, 2022 - science.org
Ligands of the transforming growth factor–β (TGF-β) superfamily, including TGF-βs, activins,
and bone morphogenetic proteins (BMPs), have been implicated in hepatic development …

Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo

W Liu, L Zhang, X Wei, Y Xu, Q Fang, S Qi, J Chen… - Carbohydrate …, 2024 - Elsevier
Ophiopogonis Radix is a well-known Traditional Chinese Medicine and functional food that
is rich in polysaccharides and has fructan as a characteristic component. In this study, an …

Host immunity and HBV S gene mutation in HBsAg-negative HBV-infected patients

X Liu, S Chen, H Liu, J Lou - Frontiers in Immunology, 2023 - frontiersin.org
Background Clinically, some patients whose HBsAg becomes negative owing to antiviral
therapy or spontaneously still show a low level of HBV DNA persistence in serum. T …

Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities

S Ahuja, S Zaheer - Cell Biology International, 2024 - Wiley Online Library
Physiological embryogenesis and adult tissue homeostasis are regulated by transforming
growth factor‐β (TGF‐β), an evolutionarily conserved family of secreted polypeptide factors …

Dynamic changes of cytokine profiles and virological markers during 48 weeks of entecavir treatment for HBeAg-positive chronic hepatitis B

M Li, Y Gao, L Yang, Y Lin, W Deng, T Jiang… - Frontiers in …, 2022 - frontiersin.org
Objective The aims of this study were to investigate the kinetic changes of serum, virological,
and immunological markers during entecavir (ETV) antiviral therapy and to explore whether …

Potentiation of Sphingolipids and TGF-β in the human corneal stroma reveals intricate signaling pathway crosstalks

SE Nicholas, AJ Choi, TN Lam, SK Basu… - Experimental Eye …, 2023 - Elsevier
Corneal haze brought on by fibrosis due to insult can lead to partial or complete vision loss.
Currently, corneal transplantation is the gold standard for treating severe corneal fibrosis …