Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins

K Hristova, ME Selsted, SH White - Journal of Biological Chemistry, 1997 - ASBMB
We have examined the interactions of the six known rabbit neutrophil defensin antimicrobial
peptides with large unilamellar vesicles (LUV) made from various lipid mixtures based on …

Antimicrobial peptides of leukocytes

T Ganz, RI Lehrer - Current opinion in hematology, 1997 - journals.lww.com
Leukocytes use an array of antimicrobial peptides and proteins to help them destroy
invading microorganisms. These endogenous antibiotic molecules are remarkable for their …

Profiling the immune response to periprosthetic joint infection and non-infectious arthroplasty failure

CR Fisher, R Patel - Antibiotics, 2023 - mdpi.com
Arthroplasty failure is a major complication of joint replacement surgery. It can be caused by
periprosthetic joint infection (PJI) or non-infectious etiologies, and often requires surgical …

The role of antimicrobial peptides in chronic inflammatory skin diseases

M Marcinkiewicz, S Majewski - Advances in Dermatology and …, 2016 - termedia.pl
Antimicrobial peptides (AMPs) are effector molecules of the innate immune system of the
skin. They present an activity against a broad spectrum of Gram-positive and Gram-negative …

Synthesis and solution structure of the antimicrobial peptide protegrin‐1

A Aumelas, M Mangoni, C Roumestand… - European Journal of …, 1996 - Wiley Online Library
Protegrins are members of a family of five Cys‐rich, cationic antimicrobial peptides recently
isolated from porcine cells. We have synthesised an 18‐amino‐acid peptide that …

Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes

R Rathinakumar, WC Wimley - Journal of the American Chemical …, 2008 - ACS Publications
Rational design and engineering of membrane-active peptides remains a largely unsatisfied
goal. We have hypothesized that this is due, in part, to the fact that some membrane …

A look at arginine in membranes

K Hristova, WC Wimley - The Journal of membrane biology, 2011 - Springer
Here, we review the current knowledge about the energetics of arginine insertion into the
bilayer hydrocarbon core, and we discuss discrepancies between experimental and …

Antibacterial peptides in hemocytes and hematopoietic tissue from freshwater crayfish Pacifastacus leniusculus: characterization and expression pattern

P Jiravanichpaisal, SY Lee, YA Kim, T Andrén… - Developmental & …, 2007 - Elsevier
A 14 amino acid residues proline/arginine-rich antibacterial peptide designated as astacidin
2 was purified and characterized from hemocytes of the freshwater crayfish, Pacifastacus …

Thia zip reaction for synthesis of large cyclic peptides: Mechanisms and applications

JP Tam, YA Lu, Q Yu - Journal of the American Chemical Society, 1999 - ACS Publications
This paper describes the mechanism and application of an efficient thia zip cyclization that
involves a series of intramolecular rearrangements in a cysteine-rich peptide for the …

[HTML][HTML] Cysteine-stabilized αβ defensins: from a common fold to antibacterial activity

R de Oliveira Dias, OL Franco - Peptides, 2015 - Elsevier
Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics,
which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ …