Very early administration of progesterone for acute traumatic brain injury

DW Wright, SD Yeatts, R Silbergleit… - … England Journal of …, 2014 - Mass Medical Soc
Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Progesterone has been shown to improve neurologic outcome in multiple experimental …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

[HTML][HTML] Neuroimaging after mild traumatic brain injury: review and meta-analysis

C Eierud, RC Craddock, S Fletcher, M Aulakh… - NeuroImage: Clinical, 2014 - Elsevier
This paper broadly reviews the study of mild traumatic brain injury (mTBI), across the
spectrum of neuroimaging modalities. Among the range of imaging methods, however …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation

DJ Loane, A Kumar, BA Stoica… - … of Neuropathology & …, 2014 - academic.oup.com
Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is …

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

A Kumar, BA Stoica, DJ Loane, M Yang… - Journal of …, 2017 - Springer
Background Local and systemic inflammatory responses are initiated early after traumatic
brain injury (TBI), and may play a key role in the secondary injury processes resulting in …

[PDF][PDF] Animal tests for anxiety-like and depression-like behavior in rats

K Belovicova, E Bogi, K Csatlosova… - Interdisciplinary …, 2017 - sciendo.com
An animal model of human behavior represents a complex of cognitive and/or emotional
processess, which are translated from animals to humans. A behavioral test is developed …

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Y Xiong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …

Translational research in traumatic brain injury

D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Traumatic brain injury: pathophysiology for neurocritical care

K Kinoshita - Journal of intensive care, 2016 - Springer
Severe cases of traumatic brain injury (TBI) require neurocritical care, the goal being to
stabilize hemodynamics and systemic oxygenation to prevent secondary brain injury. It is …