HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is
exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is …
exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is …
Photobiomodulation for traumatic brain injury and stroke
MR Hamblin - Journal of neuroscience research, 2018 - Wiley Online Library
There is a notable lack of therapeutic alternatives for what is fast becoming a global
epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near …
epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near …
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …
contributes to long-term tissue damage and poor functional outcomes. However, the …
Repeated mild traumatic brain injury: potential mechanisms of damage
B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …
accounting for the majority of all head injuries. While symptoms are generally transient …
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury
C Sarkar, Z Zhao, S Aungst, B Sabirzhanov, AI Faden… - Autophagy, 2014 - Taylor & Francis
Dysregulation of autophagy contributes to neuronal cell death in several neurodegenerative
and lysosomal storage diseases. Markers of autophagy are also increased after traumatic …
and lysosomal storage diseases. Markers of autophagy are also increased after traumatic …
[HTML][HTML] Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?
It has long been suggested that prior traumatic brain injury (TBI) increases the subsequent
incidence of chronic neurodegenerative disorders, including Alzheimer disease, Parkinson …
incidence of chronic neurodegenerative disorders, including Alzheimer disease, Parkinson …
MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury
Y Yang, Y Ye, X Su, J He, W Bai, X He - Frontiers in cellular …, 2017 - frontiersin.org
Exosomes are endosomal origin membrane-enclosed small vesicles (30–100 nm) that
contain various molecular constituents including proteins, lipids, mRNAs and microRNAs …
contain various molecular constituents including proteins, lipids, mRNAs and microRNAs …
[HTML][HTML] Cell death and recovery in traumatic brain injury
Y Akamatsu, KA Hanafy - Neurotherapeutics, 2020 - Elsevier
Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide.
Although TBI leads to mechanical damage during initial impact, secondary damage also …
Although TBI leads to mechanical damage during initial impact, secondary damage also …
Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction
C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …
Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects
FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …
provides a comprehensive and up-to-date account on the latest developments in the area of …