HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

G Wang, Y Shi, X Jiang, RK Leak… - Proceedings of the …, 2015 - National Acad Sciences
Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is
exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is …

Photobiomodulation for traumatic brain injury and stroke

MR Hamblin - Journal of neuroscience research, 2018 - Wiley Online Library
There is a notable lack of therapeutic alternatives for what is fast becoming a global
epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near …

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …

Repeated mild traumatic brain injury: potential mechanisms of damage

B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

C Sarkar, Z Zhao, S Aungst, B Sabirzhanov, AI Faden… - Autophagy, 2014 - Taylor & Francis
Dysregulation of autophagy contributes to neuronal cell death in several neurodegenerative
and lysosomal storage diseases. Markers of autophagy are also increased after traumatic …

[HTML][HTML] Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?

AI Faden, DJ Loane - Neurotherapeutics, 2015 - Elsevier
It has long been suggested that prior traumatic brain injury (TBI) increases the subsequent
incidence of chronic neurodegenerative disorders, including Alzheimer disease, Parkinson …

MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury

Y Yang, Y Ye, X Su, J He, W Bai, X He - Frontiers in cellular …, 2017 - frontiersin.org
Exosomes are endosomal origin membrane-enclosed small vesicles (30–100 nm) that
contain various molecular constituents including proteins, lipids, mRNAs and microRNAs …

[HTML][HTML] Cell death and recovery in traumatic brain injury

Y Akamatsu, KA Hanafy - Neurotherapeutics, 2020 - Elsevier
Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide.
Although TBI leads to mechanical damage during initial impact, secondary damage also …

Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …