Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal
cord injury, are leading causes of long-term disability. It is estimated that more than half of …

Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate
evolving tissue pathology. Immune cells respond to acute signals from damaged cells …

Traumatic brain injury (TBI) affects millions of people worldwide, yet there are currently no
therapeutics that address the long-term impairments that develop in a large portion of …

Background The treatment of traumatic brain injury (TBI) represents an unmet medical need,
as no effective pharmacological treatment currently exists. The development of such a …

Despite decades of basic and clinical research, treatments to improve outcomes after
traumatic brain injury (TBI) are limited. However, based on the recent recognition of the …

Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and
related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP …

Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that
contributes to neuronal damage and behavioral impairment. Toll-like receptors (TLRs) are …

Specific neurochemicals measured with proton magnetic resonance spectroscopy (1H-
MRS) may serve as biomarkers of pathological mechanism in the brain. We used high field …

Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …

Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured
proteins. In addition to their ability to prevent protein denaturation and aggregation, the …