Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a …

F Tchantchou, Y Zhang - Journal of neurotrauma, 2013 - liebertpub.com
arachidonylglycerol (2-AG) is the most abundant endocannabinoid in the central nervous
system and is elevated after brain injury. Because of its rapid hydrolysis, however, the …

Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury

NR Strogulski, LV Portela, BM Polster… - Journal of …, 2023 - Wiley Online Library
Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical
impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key …

[HTML][HTML] Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice

RJ Henry, SJ Doran, JP Barrett, VE Meadows… - …, 2019 - Elsevier
Micro-RNAs (miRs) are short, noncoding RNAs that negatively regulate gene expression at
the post-transcriptional level and have been implicated in the pathophysiology of secondary …

Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system

P Hrelia, G Sita, M Ziche, E Ristori… - Oxidative Medicine …, 2020 - Wiley Online Library
Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …

[HTML][HTML] IKK2/NF-κB signaling protects neurons after traumatic brain injury

M Mettang, SN Reichel, M Lattke, A Palmer… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is the leading cause of death in young adults. After the initial
injury, a poorly understood secondary phase, including a strong inflammatory response …

Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury

MA Naeser, PI Martin, MD Ho, MH Krengel… - … and laser surgery, 2016 - liebertpub.com
Objective: We review the general topic of traumatic brain injury (TBI) and our research
utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using …

Immuno-suppressive hydrogels enhance allogeneic MSC survival after transplantation in the injured brain

M Alvarado-Velez, SF Enam, N Mehta, JG Lyon… - Biomaterials, 2021 - Elsevier
Traumatic brain injury (TBI) triggers multiple biochemical and cellular processes that
exacerbate brain tissue damage through a secondary injury. Therapies that prevent or limit …

Pre-clinical testing of therapies for traumatic brain injury

DS DeWitt, BE Hawkins, CE Dixon… - Journal of …, 2018 - liebertpub.com
Despite the large number of promising neuroprotective agents identified in experimental
traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long …

Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?

AT Michael-Titus, JV Priestley - Trends in neurosciences, 2014 - cell.com
Omega-3 polyunsaturated fatty acids (PUFAs) are compounds that have a structural role in
the nervous system and are essential for neurodevelopment. Results obtained with …

Neuroprotection for traumatic brain injury

DJ Loane, BA Stoica, AI Faden - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …