Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Background Spaceflight poses a unique set of challenges to humans and the hostile
spaceflight environment can induce a wide range of increased health risks, including …
spaceflight environment can induce a wide range of increased health risks, including …
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
Multiple myeloma (MM) is an incurable plasma cell malignancy that exploits transcriptional
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …
SWI/SNF regulation of germinal center fate and lymphomagenesis
Q Sievers, O Abdel-Wahab - Cancer Cell, 2024 - Elsevier
The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now,
Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to …
Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to …
Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
Recent genetic and molecular classification of DLBCL has advanced our knowledge of
disease biology, yet were not designed to predict early events and guide anticipatory …
disease biology, yet were not designed to predict early events and guide anticipatory …
A bioinformatic pipeline for integration of low and high dimensional multiomic datasets
K Doshi - 2024 - open.library.ubc.ca
Follicular Lymphoma (FL) is an indolent type of Non-Hodgkin's Lymphoma comprising 20%
of new lymphoma diagnosis with a risk of transforming into a more aggressive B-cell …
of new lymphoma diagnosis with a risk of transforming into a more aggressive B-cell …