THE arterial partial pressure of carbon dioxide (Pa CO (2)) is an important regulator of the
cerebral circulation, and a large body of literature describes this relation. This review …

Nitric oxide (NO) is a potent vasodilator that was initially described as the mediator of
endothelium-dependent relaxation (endothelium-derived relaxing factor, EDRF). It is now …

Objectives: Hypocapnia is used in the management of acute brain injury and may be life-
saving in specific circumstances, but it can produce neuronal ischemia and injury, potentially …

There is increasing evidence that nitric oxide (NO) is an important molecular messenger
involved in a wide variety of biological processes. Recent data suggest that NO is also …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Conflicting data exist on the role of nitric oxide (NO) in cerebral blood flow (CBF)
autoregulation. Previous studies involving human and animal subjects seem to indicate that …

A key goal in functional neuroimaging is to use signals that are related to local changes in
metabolism and blood flow to track the neuronal correlates of mental activity. Recent …

The prostanoid-synthesizing enzyme cyclooxygenase-2 (COX-2) is expressed in selected
cerebral cortical neurons and is involved in synaptic signaling. We sought to determine …

Background—From animal studies it emerged that nitric oxide is important for the
modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the …

Mechanisms that regulate the cerebral circulation have been intensively investigated in
recent years. The role of several vasodilator mechanisms has been examined in the …