Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Cancer is an extremely complex disease, typically caused by mutations in cancer-critical
genes. By delivering therapeutic nucleic acids (NAs) to patients, gene therapy offers the …

Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …

The medical treatment for stroke has advanced greatly in recent years. Thrombolytic therapy
with tissue plasminogen activator (t-PA) is one of the mainstream treatments, but it still has …

We present a minimal model to study the effects of pH on liquid phase separation of
macromolecules. Our model describes a mixture composed of water and macromolecules …

Structurally tunable two-dimensional (2D) arrays of nanoscale objects are important for
modulating functional responses of thin films. We demonstrate that such tunable and …

DNA origami nanotechnology is being increasingly used to mimic membrane-associated
biophysical phenomena. Although a variety of DNA origami nanostructures has already …

What are the fundamental laws for the adsorption of charged polymers onto oppositely
charged surfaces, for convex, planar, and concave geometries? This question is at the heart …

In this study we derived a model for a multicomponent lipid monolayer in contact with an
aqueous solution by means of a generalized classical density functional theory and Monte …

Streaming potential and quartz crystal microbalance measurements, combined with all-atom
molecular dynamics simulations, were used to study the pH dependency of the adsorption of …