Traumatic spinal cord injury (SCI) is characterized by severe neuroinflammation and
hampered neuroregeneration, which often leads to permanent neurological deficits. Current …

Clinicians and researchers are exploring safer and novel treatment strategies for treating the
ever-prevalent Parkinson's disease (PD) across the globe. Several therapeutic strategies …

Aims Roflumilast, a well-known phosphodiesterase-4 (PDE-4) inhibitor, possess an anti-
inflammatory activity with approved indications in chronic obstructive pulmonary disease …

Perturbation of the protein homeostasis circuit is one of the principal attributes associated
with many neurodegenerative disorders, such as Parkinson's disease (PD). This study …

Huntington disease (HD), an autosomal dominant neurodegenerative disorder
characterized by involuntary choreatic movements with cognitive and behavioral …

A mutation in the Huntingtin gene causes' Huntington's disease, which presents as a motor
and behavioral impairment. Due to the limited drug therapy for this disease, scientists are …

The loss of tight junction (TJ) and adherens junction (AJ) proteins leads to the damage of the
blood-brain barrier (BBB) during cerebral ischemia. Inhibition of cyclic nucleotide …

Alzheimer's disease is a neurodegenerative disorder caused by several factors, namely
neuroinflammation, neuronal apoptosis, and low levels of neurotransmitter Acetylcholine …

Phosphodiesterase (PDE) is a superfamily of enzymes that are responsible for the
hydrolysis of two second messengers: cyclic adenosine monophosphate (cAMP) and cyclic …

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder
characterized by motor, psychiatric and cognitive symptoms. Injection of 3-nitropropionic …