[HTML][HTML] NOX1 inhibition attenuates kidney ischemia-reperfusion injury via inhibition of ROS-mediated ERK signaling
HY Jung, SH Oh, JS Ahn, EJ Oh, YJ Kim… - International Journal of …, 2020 - mdpi.com
The protective effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
(NOX) 1 inhibition against kidney ischemia-reperfusion injury (IRI) remain uncertain. The …
(NOX) 1 inhibition against kidney ischemia-reperfusion injury (IRI) remain uncertain. The …
[HTML][HTML] Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular …
JH An, SE Hong, SL Yu, J Kang, CG Park… - Journal of …, 2022 - Springer
Background Fabry disease (FD) is a lysosome storage disease (LSD) characterized by
significantly reduced intracellular autophagy function. This contributes to the progression of …
significantly reduced intracellular autophagy function. This contributes to the progression of …
[HTML][HTML] A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease
T Nagasaki, H Maeda, K Taguchi, H Yanagisawa… - Redox Biology, 2022 - Elsevier
Abstract Renal ischemia-reperfusion (IR)-induced tissue hypoxia causes impaired energy
metabolism and oxidative stress. These conditions lead to tubular cell damage, which is a …
metabolism and oxidative stress. These conditions lead to tubular cell damage, which is a …
[HTML][HTML] Honokiol protects the kidney from renal ischemia and reperfusion injury by upregulating the glutathione biosynthetic enzymes
EJ Park, T Dusabimana, J Je, K Jeong, SP Yun, HJ Kim… - Biomedicines, 2020 - mdpi.com
Glutathione (GSH) is an endogenous antioxidant found in plants, animals, fungi, and some
microorganisms that protects cells by neutralizing hydrogen peroxide. Honokiol, an active …
microorganisms that protects cells by neutralizing hydrogen peroxide. Honokiol, an active …
[HTML][HTML] Hypoxia induces renal epithelial injury and activates fibrotic signaling through up-regulation of arginase-II
The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-
arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells …
arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells …
[HTML][HTML] Neutrophils and NADPH Oxidases Are Major Contributors to Mild but Not Severe Ischemic Acute Kidney Injury in Mice
Upregulation of free radical-generating NADPH oxidases (NOX), xanthine oxidoreductase
(XOR), and neutrophil infiltration-induced, NOX2-mediated respiratory burst contribute to …
(XOR), and neutrophil infiltration-induced, NOX2-mediated respiratory burst contribute to …
[HTML][HTML] Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells
T Rousar, J Handl, J Capek, P Nyvltova… - Archives of …, 2023 - Springer
Acetaminophen (APAP) belong among the most used analgesics and antipyretics. It is
structurally derived from p-aminophenol (PAP), a potent inducer of kidney toxicity. Both …
structurally derived from p-aminophenol (PAP), a potent inducer of kidney toxicity. Both …
Small molecules as a source for acute kidney injury therapy
YL Feng, Y Yang, H Chen - Pharmacology & Therapeutics, 2022 - Elsevier
Acute kidney injury (AKI) is a sudden loss of kidney function that causes a rise in serum
creatinine and a decrease in urine output, which leads to high morbidity and mortality …
creatinine and a decrease in urine output, which leads to high morbidity and mortality …
Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro) renin Receptor‐Mediated Intrarenal Renin …
K Xue, Y Wang, Y Wang, H Fang - Oxidative Medicine and …, 2021 - Wiley Online Library
Full‐length (pro) renin receptor (fPRR), a research hotspot of the renin‐angiotensin system
(RAS), plays a serious role in kidney injury. However, the relationship between fPRR and …
(RAS), plays a serious role in kidney injury. However, the relationship between fPRR and …
Selenium deficiency leads to changes in renal fibrosis marker proteins and Wnt/β-catenin signaling pathway components
T Lin, J Tao, Y Chen, Y Zhang, F Li, Y Zhang… - … Trace Element Research, 2022 - Springer
Renal fibrosis is the final result of the progression of chronic kidney disease (CKD) to end-
stage renal disease (ESRD). Earlier studies confirmed that selenium (Se) displays a close …
stage renal disease (ESRD). Earlier studies confirmed that selenium (Se) displays a close …