Mathematical modeling for the physiological and clinical investigation of glucose homeostasis and diabetes
Mathematical modeling in the field of glucose metabolism has a longstanding tradition. The
use of models is motivated by several reasons. Models have been used for calculating …
use of models is motivated by several reasons. Models have been used for calculating …
A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development
P Gaitonde, P Garhyan, C Link, JY Chien… - Clinical …, 2016 - Springer
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, which affects millions of
people worldwide. The disease is characterized by chronically elevated blood glucose …
people worldwide. The disease is characterized by chronically elevated blood glucose …
Model‐based evaluation of proximal sodium reabsorption through SGLT2 in health and diabetes and the effect of inhibition with canagliflozin
JA Brady, KM Hallow - The Journal of Clinical Pharmacology, 2018 - Wiley Online Library
Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) reduce glucose levels in diabetes by
inhibiting renal glucose reabsorption in the proximal tubule (PT), resulting in urinary glucose …
inhibiting renal glucose reabsorption in the proximal tubule (PT), resulting in urinary glucose …
Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus
J Zhi, S Zhai - The Journal of Clinical Pharmacology, 2016 - Wiley Online Library
To assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of
piragliatin, a double‐blind, randomized, placebo‐controlled, multiple‐ascending‐doses …
piragliatin, a double‐blind, randomized, placebo‐controlled, multiple‐ascending‐doses …
Identification of the mechanism of action of a glucokinase activator from oral glucose tolerance test data in type 2 diabetic patients based on an integrated glucose …
PM Jauslin, MO Karlsson, N Frey - The Journal of Clinical …, 2012 - Wiley Online Library
A mechanistic drug‐disease model was developed on the basis of a previously published
integrated glucose‐insulin model by Jauslin et al. A glucokinase activator was used as a test …
integrated glucose‐insulin model by Jauslin et al. A glucokinase activator was used as a test …
[HTML][HTML] Glucose-insulin mathematical model for the combined effect of medications and life style of type 2 diabetic patients
The goal of this paper is to propose a new mathematical model for the combined effect of
different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) …
different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) …
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon …
KB Schneck, X Zhang, R Bauer, MO Karlsson… - … of pharmacokinetics and …, 2013 - Springer
A proof of concept study was conducted to investigate the safety and tolerability of a novel
oral glucokinase activator, LY2599506, during multiple dose administration to healthy …
oral glucokinase activator, LY2599506, during multiple dose administration to healthy …
Influence of meals and glycemic changes on QT interval dynamics
B Cirincione, PT Sager… - The Journal of Clinical …, 2017 - Wiley Online Library
Thorough QT/QTc studies have become an integral part of early drug development
programs, with major clinical and regulatory implications. This analysis expands on existing …
programs, with major clinical and regulatory implications. This analysis expands on existing …
Modelling of fasting glucose-insulin dynamics from sparse data
TB Aradóttir, D Boiroux, H Bengtsson… - 2018 40th Annual …, 2018 - ieeexplore.ieee.org
With the fast growth of diabetes prevalence, the disease is now considered an epidemic.
Diabetes is characterized by elevated glucose levels, that may be treated with insulin. Tight …
Diabetes is characterized by elevated glucose levels, that may be treated with insulin. Tight …
Transient lower esophageal sphincter relaxation pharmacokinetic-pharmacodynamic modeling: count model and repeated time-to-event model
EL Plan, G Ma, M Någård, J Jensen… - Journal of Pharmacology …, 2011 - ASPET
Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for
gastroesophageal reflux. Characterizations of candidate compounds for reduction of …
gastroesophageal reflux. Characterizations of candidate compounds for reduction of …