Mathematical modeling in the field of glucose metabolism has a longstanding tradition. The
use of models is motivated by several reasons. Models have been used for calculating …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, which affects millions of
people worldwide. The disease is characterized by chronically elevated blood glucose …

Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) reduce glucose levels in diabetes by
inhibiting renal glucose reabsorption in the proximal tubule (PT), resulting in urinary glucose …

To assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of
piragliatin, a double‐blind, randomized, placebo‐controlled, multiple‐ascending‐doses …

A mechanistic drug‐disease model was developed on the basis of a previously published
integrated glucose‐insulin model by Jauslin et al. A glucokinase activator was used as a test …

The goal of this paper is to propose a new mathematical model for the combined effect of
different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) …

A proof of concept study was conducted to investigate the safety and tolerability of a novel
oral glucokinase activator, LY2599506, during multiple dose administration to healthy …

Thorough QT/QTc studies have become an integral part of early drug development
programs, with major clinical and regulatory implications. This analysis expands on existing …

With the fast growth of diabetes prevalence, the disease is now considered an epidemic.
Diabetes is characterized by elevated glucose levels, that may be treated with insulin. Tight …

Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for
gastroesophageal reflux. Characterizations of candidate compounds for reduction of …