The Story of RNA Unfolded: The Molecular Function of DEAD-and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles
K Dörner, M Hondele - Annual Review of Biochemistry, 2024 - annualreviews.org
DEAD-and DExH-box ATPases (DDX/DHXs) are abundant and highly conserved cellular
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
[HTML][HTML] Understanding the cell: Future views of structural biology
Determining the structure and mechanisms of all individual functional modules of cells at
high molecular detail has often been seen as equal to understanding how cells work …
high molecular detail has often been seen as equal to understanding how cells work …
[HTML][HTML] Subcytoplasmic location of translation controls protein output
The cytoplasm is highly compartmentalized, but the extent and consequences of
subcytoplasmic mRNA localization in non-polarized cells are largely unknown. We …
subcytoplasmic mRNA localization in non-polarized cells are largely unknown. We …
[HTML][HTML] Regulation by the RNA-binding protein Unkempt at its effector interface
How RNA-binding proteins (RBPs) convey regulatory instructions to the core effectors of
RNA processing is unclear. Here, we document the existence and functions of a multivalent …
RNA processing is unclear. Here, we document the existence and functions of a multivalent …
[HTML][HTML] Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization
R Asada, A Dominguez, B Montpetit - Cell reports, 2023 - cell.com
RNA-binding proteins (RBPs) interact with mRNA to form supramolecular complexes called
messenger ribonucleoprotein (mRNP) particles. These dynamic assemblies direct and …
messenger ribonucleoprotein (mRNP) particles. These dynamic assemblies direct and …
UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2
LM Langer, K Kurscheidt, J Basquin… - Nucleic Acids …, 2024 - academic.oup.com
Nonsense-mediated mRNA decay (NMD) is a conserved co-translational mRNA
surveillance and turnover pathway across eukaryotes. NMD has a central role in degrading …
surveillance and turnover pathway across eukaryotes. NMD has a central role in degrading …
Arabidopsis mRNA export factor MOS11: molecular interactions and role in abiotic stress responses
A Rödel, I Weig, S Tiedemann, U Schwartz… - New …, 2024 - Wiley Online Library
Transcription and export (TREX) is a multi‐subunit complex that links synthesis, processing
and export of mRNAs. It interacts with the RNA helicase UAP56 and export factors such as …
and export of mRNAs. It interacts with the RNA helicase UAP56 and export factors such as …
[HTML][HTML] The Molecular Architecture of the Nuclear Basket
The nuclear pore complex (NPC) is the sole mediator of nucleocytoplasmic transport.
Despite great advances in understanding its conserved core architecture, the peripheral …
Despite great advances in understanding its conserved core architecture, the peripheral …
Cross-linking mass spectrometric analysis of the endogenous TREX complex from Saccharomyces cerevisiae
C Kern, C Radon, W Wende, A Leitner, K Sträßer - RNA, 2023 - rnajournal.cshlp.org
The conserved TREX complex has multiple functions in gene expression such as
transcription elongation, 3′ end processing, mRNP assembly and nuclear mRNA export as …
transcription elongation, 3′ end processing, mRNP assembly and nuclear mRNA export as …
[HTML][HTML] A paradigm for regulation at the effector interface with RNA-binding proteins
RNA-binding proteins (RBPs) are key regulators of gene expression, but how RBPs convey
regulatory instructions to the core effectors of RNA processing is unclear. Here we document …
regulatory instructions to the core effectors of RNA processing is unclear. Here we document …