Organisms living in an aerobic environment were forced to evolve effective cellular
strategies to detoxify reactive oxygen species. Besides diverse antioxidant enzymes and …

In contrast to the traditional biochemical study of single proteins or isolated pathways in
health and disease, technical advances in the high-throughput screening of peptides by …

To investigate molecular mechanisms of human brain aging, brain proteins were isolated
from postmortem human young and old brains and profiled by two‐dimensional gel …

We investigated the protein profiles of variously aged rat astrocytes in response to oxidative
stress. After H2O2‐exposure of cells at 100 µm for 30 min, the relative intensity of ten protein …

Peroxisome proliferator‐activated receptor α (PPARα) is a member of the nuclear receptor
family, regulating fatty acid degradation in many organs. Two‐dimensional SDS‐PAGE of …

Free radicals have been implicated in the development of many acute and chronic diseases
and in conditions involving brain or neurological tissue. The primary genetic material is …

Peroxisome proliferator-activated receptor α (PPARα) belongs to the steroid/nuclear
receptor superfamily. Two-dimensional (2D) SDS–PAGE analysis of brown adipose tissue …

Abstract Two‐dimensional (2‐D) electrophoresis is a very useful technique for the analysis
of proteins in biological tissues. The complexity of the 2‐D maps obtained causes many …

Three-way PCA has been applied to proteomic pattern images to identify the classes of
samples present in the dataset. The developed method has been applied to two different …

Aging is accompanied by the changes in the cells that decrease their capacity to respond to
various forms of stress. Cells are known to respond to stresses through expression of stress …