Neurodegenerative diseases including Alzheimer's disease, Parkinson's disease,
Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …

The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …

Brain tumor targeted delivery of diagnostic contrast agents has been an elusive goal due to
the presence of the blood brain barrier (BBB) and the complex brain tumor …

The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …

Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective
therapies is a pharmaceutical challenge and an unmet medical need. Photothermal therapy …

Purpose: Glioblastoma (GBM) is the most common primary malignant tumor in the central
nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an …

Lauroyl-gemcitabine lipid nanocapsules (GemC 12-LNC) hydrogel, administered
intratumorally or perisurgically in the tumor resection cavity, increases animal survival in …

Diseases affecting the central nervous system (CNS) should be regarded as a major health
challenge due to the current lack of effective treatments given the hindrance to brain drug …