Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model
X Cao, ST Gibbs, L Fang, HA Miller… - Pharmaceutical …, 2006 - Springer
Purpose To study the correlation of intestinal absorption for drugs with various absorption
routes between human and rat, and to explore the underlying molecular mechanisms for the …
routes between human and rat, and to explore the underlying molecular mechanisms for the …
[HTML][HTML] Drug disposition in the lower gastrointestinal tract: targeting and monitoring
G Lemmens, A Van Camp, S Kourula, T Vanuytsel… - Pharmaceutics, 2021 - mdpi.com
The increasing prevalence of colonic diseases calls for a better understanding of the various
colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools …
colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools …
Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol)
L Kalantzi, C Reppas, JB Dressman, GL Amidon… - Journal of …, 2006 - Elsevier
Literature data are reviewed on the properties of acetaminophen (paracetamol) related to
the biopharmaceutics classification system (BCS). According to the current BCS criteria …
the biopharmaceutics classification system (BCS). According to the current BCS criteria …
Standardization of an ex vivo method for determination of intestinal permeability of drugs using everted rat intestine apparatus
INTRODUCTION: Everted gut sac of rat intestine is a paradigm widely employed for
determination of absorption kinetics of drugs along with evaluation of effects of absorption …
determination of absorption kinetics of drugs along with evaluation of effects of absorption …
Proliposomes of exemestane for improved oral delivery: formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine
PS Hiremath, KS Soppimath, GV Betageri - International journal of …, 2009 - Elsevier
The aim of the present study was to develop proliposomal formulations to enhance the oral
bioavailability of exemestane by improving solubility, dissolution and/or intestinal …
bioavailability of exemestane by improving solubility, dissolution and/or intestinal …
[HTML][HTML] Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using box behnken design
B Gajra, C Dalwadi, R Patel - DARU Journal of Pharmaceutical Sciences, 2015 - Springer
Background The objective of the study was to formulate and to investigate the combined
influence of 3 independent variables in the optimization of Polymeric lipid hybrid …
influence of 3 independent variables in the optimization of Polymeric lipid hybrid …
pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation
B Fan, Y Xing, Y Zheng, C Sun, G Liang - Drug delivery, 2016 - Taylor & Francis
The aim of present study was to investigate a pH-responsive and mucoadhesive
nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin …
nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin …
Evaluation of the permeability and P‐glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique
Purpose: The rational discovery and development of new antiepileptic drugs (AEDs) with
safer therapeutic index and better pharmacokinetic properties is still warranted nowadays …
safer therapeutic index and better pharmacokinetic properties is still warranted nowadays …
In vitro screening models to assess intestinal drug absorption and metabolism
S Deferme, P Annaert, P Augustijns - Drug absorption studies: In situ, in …, 2008 - Springer
Compounds intended for oral administration must have adequate biopharmaceutical
properties in order to achieve therapeutic concentrations at the targeted site of action …
properties in order to achieve therapeutic concentrations at the targeted site of action …
A novel in vitro membrane permeability methodology using three-dimensional caco-2 tubules in a microphysiological system which better mimics in vivo physiological …
Y Hagiwara, H Kumagai, N Ouwerkerk, L Gijzen… - Journal of …, 2022 - Elsevier
The aim of this study was to develop an in vitro drug permeability methodology which mimics
the gastrointestinal environment more accurately than conventional 2D methodologies …
the gastrointestinal environment more accurately than conventional 2D methodologies …