Gene therapy in orthopaedics: progress and challenges in pre-clinical development and translation

RS Watson-Levings, GD Palmer, PP Levings… - … in Bioengineering and …, 2022 - frontiersin.org
In orthopaedics, gene-based treatment approaches are being investigated for an array of
common-yet medically challenging-pathologic conditions of the skeletal connective tissues …

Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapy

LO Afolabi, MO Afolabi, MM Sani… - Clinical & …, 2021 - Wiley Online Library
The discovery of clustered regularly interspaced short palindromic repeats and CRISPR‐
associated protein 9 (CRISPR‐Cas9) technology has brought advances in the genetic …

CRISPR/Cas12a Powered DNA Framework‐Supported Electrochemical Biosensing Platform for Ultrasensitive Nucleic Acid Analysis

J Su, Y Ke, N Maboyi, X Zhi, S Yan, F Li, B Zhao… - Small …, 2021 - Wiley Online Library
Nucleic acid analysis using ultrasensitive and simple methods is critically important for the
early‐stage diagnosis and treatment of diseases. The CRISPR/Cas proteins, guided by a …

[HTML][HTML] The progress of CRISPR/Cas9-mediated gene editing in generating mouse/zebrafish models of human skeletal diseases

N Wu, B Liu, H Du, S Zhao, Y Li, X Cheng… - Computational and …, 2019 - Elsevier
Genetic factors play a substantial role in the etiology of skeletal diseases, which involve 1)
defects in skeletal development, including intramembranous ossification and endochondral …

[HTML][HTML] CRISPR–Cas system and its use in the diagnosis of infectious diseases

V Padmanaban, UDK Ranganathan - Microbiological Research, 2022 - Elsevier
Rapid and accurate diagnostic methods for detecting pathogens are needed for effective
management and treatment of infectious diseases. The conventional pathogen detection …

A Chinese model for legal regulation of Gene-Edited endangered animals and plants

T Li - Gene, 2024 - Elsevier
Background The application of gene editing technology in the field of endangered plant and
animal conservation has innovative and prospective value in saving endangered plant and …

The End of Snoring? Application of CRISPR/Cas9 Genome Editing for Sleep Disorders

E Murillo-Rodríguez, NB Rocha, AB Veras, H Budde… - Sleep and Vigilance, 2018 - Springer
Science selected it as the 2015 Breakthrough of the Year: Clustered Regularly Interspaced
Short Palindromic Repeats, also known as CRISPR. Adaptive immunity in some bacteria …

Amine detection in aquatic organisms: receptor evolution, neuronal circuits and behavior in the model organism zebrafish

M Dieris - 2018 - kups.ub.uni-koeln.de
Olfactory cues are responsible for the generation of diverse behaviors in the animal
kingdom. Olfactory receptors are expressed by specialized sensory neurons (OSNs) in the …

Edição genética associada ao uso da nova técnica CRISPR/Cas9, ferramenta de defesa utilizada pelas bactérias contra DNA invasor.

AA Lins, PL MELLO, FB GONÇALVES - Revista Eletrônica Científica …, 2018 - 200.132.92.80
O tema edição genética é algo que ainda traz muitas dúvidas as pessoas, afinal, o material
genético é tudo aquilo que forma uma pessoa, tudo aquilo que se herdou e que irá passar …

CRISPR-Cas Associated Cells and Animal Mediated Biomedical Modelling

T Nazir, HA Mirza, N Rao - 2024 - preprints.org
Gene editing is now easy to make new disease models through in-vivo and in vitro tests. It
can potentially be used to make animals with single-gene or multiple-gene changes. The …