Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

The treatment of myocardial infarction (MI) remains a substantial challenge due to excessive
inflammation, massive cell death, and restricted regenerative potential, leading to …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Background Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have
been considered as a promising cell-free therapeutic strategy for ischemic heart disease …

Macrophages are present in almost all organs. Apart from being immune sentinels, tissue-
resident macrophages (TRMs) have organ-specific functions that require a specialized …

Rationale: Ischemic stroke poses a significant health burden with limited treatment options.
Lymphocyte Cytosolic Protein 1 (LCP1) facilitates cell migration and immune responses by …

Inflammation is a major underlying mechanism in the progression of numerous
cardiovascular diseases (CVDs). Regulatory T cells (Tregs) are typical immune regulatory …

Galectin-3 (Gal-3) is a carbohydrate-binding protein with multiple functions. Gal-3 regulates
cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions …