Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous
system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein …

Fatty liver index (FLI) was developed as a simple and accurate marker of hepatic steatosis.
FLI is derived from an algorithm based on body mass index, waist circumference, and levels …

Background Fatty acid-derived lipid mediators including oxylipins, endocannabinoids
(eCBs), and their analogues, have emerged as key metabolites in the inflammatory and …

Our previous studies support a key role for mitochondrial lipid hydroperoxides as important
contributors to denervation-related muscle atrophy, including muscle atrophy associated …

Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …

This manuscript reviews the CYP-mediated production of oxylipins and the current known
function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families …

Pre-clinical studies suggest that circulating oxylipins, ie, the oxidation products of
polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there …

The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk
factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male …

Abstract Omega-6 and omega-3 oxylipins may be surrogate markers of systemic
inflammation, which is one of the triggers for the development of cardiometabolic disorders …

Koumine is an alkaloid with significant anti-anxiety, anticancer cell proliferation, and
analgesic activities, and our previous studies have shown that koumine can be used as an …