Delivering therapeutic agents into cells has always been a major challenge. In recent years,
cyclization emerged as a tool for designing CPPs to increase their internalization and …

Cell-penetrating peptides (CPPs) are commonly modified to increase their cellular uptake,
alter the mechanism of penetration or enhance their endosomal release. Earlier, we …

This review summarizes recent developments in conjugation techniques for the synthesis of
cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. We will focus on …

Cell-penetrating peptides (CPPs) are promising delivery vehicles. These short peptides can
transport wide range of cargos into cells, although their usage has often limitations. One of …

The cell-penetrating peptide (CPP) penetratin has gained much attention over many years
due to its potential role as a transporter for a broad range of cargo into cells. The …

Researchers still hold for the development of a safety and advanced delivery system able of
efficient therapeutic action. The co-delivery of different payloads is part of this strategy and …

A series of novel 6-substituted pyrrolo [3, 2-d] pyrimidine analogues (10a, 11a-13a, 15a,
17a, 18a, 27a and 28a) have been designed and synthesized as antifolate antitumor agents …

Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they
take part in the regulation of many cellular functions such as cell division, differentiation or …

This review concentrates on the research concerning conjugates of anticancer drugs with
versatile cell-penetrating peptides (CPPs). For a better insight into the relationship between …

Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor
drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus …