New drug discovery has been acknowledged as a complicated, expensive, time-consuming,
and challenging project. It has been estimated that around 12 years and 2.7 billion USD, on …

Ethnopharmacology, through the description of the beneficial effects of plants, has provided
an early framework for the therapeutic use of natural compounds. Natural products, either in …

Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor
tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal …

Analyses of compounds in clinical development have shown that ligand efficient-molecules
with privileged physical properties and low dose are less likely to fail in the various stages of …

The development of a versatile platform for the synthesis of 1, 2-difunctionalized bicyclo [1.1.
1] pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses …

Introduction Current treatment for age-related macular degeneration poses a large burden
on patients and the inability of patients to adhere to this immense burden can lead to worse …

Background Axitinib is an oral small molecule that inhibits receptor tyrosine kinases vascular
endothelial growth factor receptors 1 to 3. A phase 1 and pharmacokinetic (PK) trial …

The clinical treatment of multifactorial pathologies (eg cancer, Alzheimer's disease,
psychiatric disorders), is still a major challenge. Many researches have been published …

Kinases are among the most important families of biomolecules and play an essential role in
the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological …

Angiogenesis in general and the vascular endothelial growth factor (VEGF) signaling axis in
particular is a validated target in renal cell carcinoma (RCC). Clear-cell carcinoma of the …