Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …

Humanized mouse models can be used to explore human gene regulatory elements (REs),
which frequently lie in non-coding and less conserved genomic regions. Epigenetic …

The complex dyadic interaction of stress and resilience has received growing attention as a
promising avenue for informing new diagnostic and prognostic models for human health. In …

Most proteins are flexible molecules that coexist in an ensemble of several conformations.
Point mutations in the amino acid sequence of a protein can trigger structural changes that …

Abstract FK506-binding protein 51 kDa (FKBP51), encoded by Fkbp5 gene, gained
considerable attention as an important regulator of several aspects of human biology …

Relapse is a fundamental challenge in drug addiction, often evoked by exposure to drug-
associated cues. Upon retrieval, memories become temporarily labile before re-stabilizing in …

FK506-binding protein 51 kDa (FKBP51), encoded by Fkbp5 gene, gained considerable
attention as an important regulator of several aspects of human biology including stress …

The increasing prevalence of stress-related disorders, such as major depressive disorder
(MDD) has become a significant global concern, with devastating effects on individuals' …

IRSp53 is a synaptic scaffold protein reported to be involved in schizophrenia, autism
spectrum disorders, and social deficits in knockout mice. Identifying critical brain regions and …