Positron emission tomography (PET) provides metabolic information that has been
documented to be useful in patient care. The properties of positron decay permit accurate …

Quantitative positron emission tomography (PET) brain studies often require that the input
function be measured, typically via arterial cannulation. Image-derived input function (IDIF) …

The normal aging human brain experiences global decreases in metabolism, but whether
this affects the topography of brain metabolism is unknown. Here we describe PET-based …

Monte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to
their detailed description of radiation transport and interaction with matter. The suitability of a …

Semiquantitative standard uptake values (SUVs) are used for tumor diagnosis and response
monitoring. However, the accuracy of the SUV and the accuracy of relative change during …

Background: Patients with amnestic mild cognitive impairment (MCI) represent an important
clinical group as they are at increased risk of developing Alzheimer disease (AD). 11C-PIB …

[11C](R) PK11195-PET is a marker of activated microglia while [11C] PIB-PET detects raised
amyloid load. Here we studied in vivo the distributions of amyloid load and microglial …

Background: Studies in experimental animals have implicated the mesolimbic dopaminergic
projections into the ventral striatum in the neural processes underlying behavioral …

Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and …

A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile
plaques in the brain. Evidence is accumulating that decreased clearance of amyloid-β from …