The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …

[HTML][HTML] Inflammatory responses and inflammation-associated diseases in organs

L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng, Y Li… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Patrolling alveolar macrophages conceal bacteria from the immune system to maintain homeostasis

AS Neupane, M Willson, AK Chojnacki… - Cell, 2020 - cell.com
During respiration, humans breathe in more than 10,000 liters of non-sterile air daily,
allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar …

Innate immune responses to trauma

M Huber-Lang, JD Lambris, PA Ward - Nature immunology, 2018 - nature.com
Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Functional role of dietary intervention to improve the outcome of COVID-19: a hypothesis of work

G Messina, R Polito, V Monda, L Cipolloni… - International journal of …, 2020 - mdpi.com
Background: On the 31 December 2019, the World Health Organization (WHO) was
informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City …

[HTML][HTML] Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

CN Serhan - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Contributions of eosinophils to human health and disease

AD Klion, SJ Ackerman… - Annual Review of …, 2020 - annualreviews.org
The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …

Anti-inflammatory effects of resveratrol: Mechanistic insights

D de Sá Coutinho, MT Pacheco, RL Frozza… - International journal of …, 2018 - mdpi.com
Inflammation is the principal response invoked by the body to address injuries. Despite
inflammation constituting a crucial component of tissue repair, it is well known that …

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

N Chiang, CN Serhan - Molecular aspects of medicine, 2017 - Elsevier
The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …