Multiple sclerosis (MS) is a central nervous system disorder mainly characterized by
inflammation, demyelination and axonal injury. Anti-inflammatory agents can be used to …

Hyperforin, the major lipophilic compound contained in extracts of Hypericum perforatum, is
responsible for the antidepressant activity associated with the extract. Recently, several …

The deregulation of dietary supplements and natural products marketing by the FDA has
widened the natural products market in Europe and worldwide. While the discussion about …

The phloroglucinol derivative hyperforin, a major bioactive constituent of St. John's wort, is
increasingly recognized as being able to regulate a variety of pathobiological processes …

Hyperforin is a prenylated phloroglucinol present in the medicinal plant St John's wort
(Hypericum perforatum). The compound has many biological properties, including …

Cardiovascular diseases and cancer are the leading causes of death in most countries.
These diseases share many common risk factors as well as pathogenetic determinants, and …

Photodynamic therapy is a rapidly-developing anti-cancer approach for the treatment of
various types of malignant as well as non-malignant diseases. In this study, hypericin …

Human diets are rich in secondary metabolites such as polyphenols. These compounds
perform a wide range of crucial functions in biological systems and are of great interest for …

Hyperforin (1) is a polyprenylated acylphloroglucinol (PPAP) natural product isolated in
1971 from Hypericum perforatum. Also known as St. John's wort, Hypericum perforatum is a …

Upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic
and release pro-inflammatory mediators like nitric oxide (NO). Excessive NO production is …