Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Diabetes mellitus has been recognised as one of the four major non-communicable
diseases that demands urgent attention from all key shareholders globally in an effort to …

Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease,
is the leading cause of visual impairment in diabetic patients. Many clinical features …

Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

The ang opoietin/t yrosine kinase with i mmunoglobulin and e pidermal growth factor
homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development …

Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness worldwide.
Since DR was first recognized as an important complication of diabetes, there have been …

Retinal endothelial cells (RECs) are the primary target cells for diabetes-induced vascular
damage. The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via …