Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …

Metformin is the most often prescribed drug for people with type 2 diabetes (T2D). More than
120 million patients with T2D use metformin worldwide. However, monotherapy fails to …

In our modern society, where highly palatable and calorie-rich foods are readily available,
and sedentary lifestyle is common among children and adolescents, we face the pandemic …

Abstract Background As Wnt/β-catenin/glycogen synthase kinase 3β (GSK3β) signaling has
been implicated in myocardial injury and diabetic cardiomyopathy (DCM) is a major part of …

Context: Wnt/β-catenin signaling is related to the pathogenesis of osteoporosis, diabetes,
and metabolic diseases. Sclerostin is an inhibitor of Wnt/β-catenin signaling. However, there …

Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density
lipoprotein receptor family and has a unique structure, which facilitates its multiple functions …

Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity,
elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The …

Common genetic variations in Wnt signaling genes have been associated with metabolic
syndrome and diabetes by mechanisms that are poorly understood. A rare nonconservative …

Retinal neovascular, neurodegenerative, and inflammatory diseases represented by
diabetic retinopathy are the main types of blinding eye disorders that continually cause the …