During in vitro culture, bereft of their optimal tissue context, tenocytes lose their phenotype
and function. Considering that tenocytes in their native tissue milieu are exposed …

Improved strategies for the treatment of tendon defects are required to successfully restore
mechanical function and strength to the damaged tissue. This remains a scientific and …

Purpose We create a viable, mechanically expanded autograft long head biceps tendon
(LHBT) scaffold for biologically augmenting the repair of torn rotator cuffs. Methods The …

Mesenchymal stromal cells (MSC) represent a promising therapeutic tool for tendon
regeneration. Their tenogenic differentiation is crucial for tissue engineering approaches …

Fertility preservation and assisted reproductive medicine require effective culture systems for
the successful proliferation and differentiation of spermatogonial stem cells (SSCs). Many …

Aim: Currently there is no effective approach to enhance tendon repair, hence we aimed to
identify a suitable cell source for tendon engineering utilizing an established clinically …

Tendinopathies negatively affect the life quality of millions of people in occupational and
athletic settings, as well as the general population. Tendon healing is a slow process, often …

Hydrogel scaffolds derived from the extracellular matrix (ECM) of mammalian tissues have
been successfully used to promote tissue repair in vitro and in vivo. The objective of this …

The native extracellular matrix (ECM) provides a matrix to hold tissue/organ, defines the
cellular fate and function, and retains growth factors. Such a matrix is considered as a most …

The extracellular matrix (ECM) is known to regulate tissue development and cell
morphology, movement, and differentiation. SPARCL1 is an ECM protein, but its role in …