Achilles tendon reconstruction surgery is the primary clinical method for repairing acute
Achilles tendon ruptures. However, the efficacy of the postoperative healing process and the …

Abstract Setting time as the fourth dimension, 4D printing allows us to construct dynamic
structures that can change their shape, property, or functionality over time under stimuli …

Background: Despite the clinical potential of adipose-derived stem/stromal cells (ASCs),
there are some clinical difficulties due to the regulation of cell therapies. Materials & …

As our ability to engineer nanoscale materials has developed we can now influence
endogenous cellular processes with increasing precision. Consequently, the use of …

Efforts to generate tissue-engineered anterior cruciate ligament replacements are limited by
a lack of methods to derive mature ligament cells. Viral overexpression of the …

Mechanical loading may be required for proper tendon formation. However, it is not well
understood how tendon formation is impacted by the development of weight-bearing …

Background: Achilles tendon (AT) defects often occur in traumatic and chronic injuries.
Currently, no graft can satisfactorily regenerate parallel tendinous tissue at the defect site to …

Healing of dense regular connective tissue, due to a high fiber-to-cell ratio and low
metabolic activity and regeneration potential, frequently requires surgical implantation or …

Background aims Tendon is a complex tissue with a reduced regenerative ability.
Nowadays, little or nothing is known about the regenerative effect of adipose-derived …

Tendon injuries are common musculoskeletal system disorders, but the tendons have poor
regeneration ability. To address this issue, tendon tissue engineering provides potential …