Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension
IAM Brown, L Diederich, ME Good… - … , and vascular biology, 2018 - Am Heart Assoc
Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …
[HTML][HTML] Molecular genetics of human obesity: A comprehensive review
Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …
and their signalling molecules play a critical role in the intervening and coordination with …
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions
through incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r …
through incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r …
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Meta-analyses of association results for blood pressure using exome-centric single-variant
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
Genetic and molecular aspects of hypertension
S Padmanabhan, M Caulfield… - Circulation research, 2015 - Am Heart Assoc
Until recently, significant advances in our understanding of the mechanisms of blood
pressure regulation arose from studies of monogenic forms of hypertension and …
pressure regulation arose from studies of monogenic forms of hypertension and …
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression
M Trudu, S Janas, C Lanzani, H Debaix, C Schaeffer… - Nature medicine, 2013 - nature.com
Hypertension and chronic kidney disease (CKD) are complex traits representing major
global health problems 1, 2. Multiple genome-wide association studies have identified …
global health problems 1, 2. Multiple genome-wide association studies have identified …
Removal of drug losartan in environmental aquatic matrices by heat-activated persulfate: Kinetics, transformation products and synergistic effects
In this study, the oxidative degradation of losartan (LOS), a widely administered medicine for
high blood pressure by heat-activated persulfate was investigated. Increased temperature …
high blood pressure by heat-activated persulfate was investigated. Increased temperature …
Pressure natriuresis and the renal control of arterial blood pressure
The regulation of extracellular fluid volume by renal sodium excretion lies at the centre of
blood pressure homeostasis. Renal perfusion pressure can directly regulate sodium …
blood pressure homeostasis. Renal perfusion pressure can directly regulate sodium …
Risk of hypertension into adulthood in persons born prematurely: a national cohort study
C Crump, J Sundquist, K Sundquist - European Heart Journal, 2020 - academic.oup.com
Aims Preterm birth has been associated with elevated blood pressure early in life; however,
hypertension risks from childhood into adulthood remain unclear. We conducted a large …
hypertension risks from childhood into adulthood remain unclear. We conducted a large …