Context Evaluation of the infertile female requires an understanding of ovulation and
biomarkers of ovarian reserve. Antimüllerian hormone (AMH) correlates with growing …

Infertility impacts a considerable number of women worldwide, and it affects different aspects
of family life and society. Although female infertility is known as a multifactorial disorder …

STUDY QUESTION Do specific transcriptome dynamics in human oocytes from primordial
and primary follicles identify novel pathways in oocyte activation? SUMMARY ANSWER The …

Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed
therapeutically by alternative routes for oocyte formation. Here, we describe the generation …

Context Primary ovarian insufficiency (POI) encompasses a spectrum of premature
menopause, including both primary and secondary amenorrhea. For 75% to 90% of …

STUDY QUESTION Can novel genetic candidates involved in follicle dormancy, activation
and integrity be identified from transcriptomic profiles of isolated granulosa cells from human …

Background Previous studies have reported that transplantation of mesenchymal stem cells
(MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study …

In mammals, females are born with finite numbers of oocytes stockpiled as primordial
follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their …

Human infertility is often classified as idiopathic in both males and females. Meiotic errors
may account for at least part of these cases. As the synaptonemal complex (SC, a meiosis …

Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in
women and affects about one per cent of young women. This disorder has significant …